Accepted by Scopus and Clarivate Analytics to be indexed in Science Citation Index Expanded, JCR, Current Contents and Biological Abstracts

CDC/ C Goldsmith, P Feorino, EL Palmer, WR McManus

Efforts to eliminate the latent reservoir in resting CD4+ T cells: strategies for curing HIV-1 infection

Author List
Ya-Chi Ho
Janet D Siliciano

Abstract

Since the introduction of the first antiretroviral drug, zidovudine, in 1987, over 25 different antiretroviral agents from six different drug classes have been approved for the treatment of HIV-1 infection. Today, combination antiretroviral therapy (ART) is extremely effective in suppressing HIV-1 replication, providing durable control of the virus in adherent patients. However, despite the effectiveness of ART in blocking viral replication, HIV-1 infection cannot be cured by ART alone because HIV-1 establishes a state of latent infection in a small pool of resting, memory CD4+ T cells. Some new developments in the search for a cure are discussed.

Article Category

HIV cure research

Article Type

Reviews

Posted Date

01-10-2015

Tables & Figures

Back to top