Fimepinostat, a novel dual inhibitor of HDAC and PI3K, effectively reverses HIV-1 latency ex vivo without T cell activation

Author List
Jesper Gunst
Kathrine Kjær
Rikke Olesen
Thomas Rasmussen
Lars Østergaard
Paul Denton
Ole Søgaard
Martin Tolstrup

Abstract

Latent, integrated HI V type 1 (HI V-1) proviruses persist predominantly in memory CD4+ T cells among individuals living with HI V-1 despite effective combination antiretroviral therapy (cAR T) [1–3] This latent reservoir is thought to be the main barrier preventing long-term remission off cART.

Article Category

HIV reservoir

Article Type

Original research

Posted Date

02-07-2019

Tables & Figures

Back to top