HIV-1 elite controllers: an immunovirological review and clinical perspectives

Author List
Nour Gebara
Vanessa El Kamari
Nesrine Rizk

Abstract

HIV type 1 (HIV -1) elite controllers (ECs) represent a rare group of individuals with an ability to maintain an undetectable HIV -1 viral load overtime in the absence of previous antiretroviral therapy. The mechanisms associated with this paradigm remain not clearly defined.

HIV type 1 (HIV -1) elite controllers (ECs) represent a rare group of individuals with an ability to maintain an undetectable HIV -1 viral load overtime in the absence of previous antiretroviral therapy. The mechanisms associated with this paradigm remain not clearly defined. However, loss of virological control, morbidity and mortality persist in these individuals, such as progress to AIDS-defining conditions together with persistent high rate of immune activation. Further insight into potential therapeutic options is therefore warranted. In this review, we discuss recent data on the type of immune responses understood to be associated with chronic virological control, the potential for disease progression and therapeutic options in ECs.

Article Category

HIV cure research

Article Type

Original research

Posted Date

02-07-2019

File Name
1562080317jve_5_3_01_Gebara_rev.pdf

HIV-1 elite controllers: an immunovirological review and clinical perspectives

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