CDC/ C Goldsmith, P Feorino, EL Palmer, WR McManus
HIV-infected cells are frequently clonally expanded after prolonged antiretroviral therapy: implications for HIV persistence
AbstractHIV infection is controlled but not eradicated by combination antiretroviral therapy (cART), and persistence during therapy represents a substantial barrier to strategies to eradicate infection. The nature of persistence is uncertain, and a number of mechanisms have been proposed to explain HIV persistence in vivo, including low-level HIV replication, sanctuary sites for HIV-infected cells, and latent HIV residing within long-lived cells.
HIV cure research