Highlights from the Keystone Symposium on HIV Persistence 2015 26–30 April 2015, Boston, Massachusetts, USA
AbstractDespite long-term control of HIV replication with combination antiretroviral therapy, HIV persists as quiescent integrated DNA in memory CD4+ T cells, and possibly in other cellular reservoirs, including naïve cells and macrophages. Low-level replenishment of the reservoir via limited cycles of replication, may also contribute to persistence, at least in some patients. Curing HIV infection will only occur if these barriers are reversed, or if host capacity to control HIV indefinitely is improved.
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