CDC/ C Goldsmith, P Feorino, EL Palmer, WR McManus

HIV-infected cells are frequently clonally expanded after prolonged antiretroviral therapy: implications for HIV persistence

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F Maldarelli


HIV infection is controlled but not eradicated by combination antiretroviral therapy (cART), and persistence during therapy represents a substantial barrier to strategies to eradicate infection. The nature of persistence is uncertain, and a number of mechanisms have been proposed to explain HIV persistence in vivo, including low-level HIV replication, sanctuary sites for HIV-infected cells, and latent HIV residing within long-lived cells.

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HIV cure research

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